Figure 11

Effect of isoproterenol and increase in [ Ca^{2 +}] _o . Role of isoproterenol and [C a^{2 +} ] _o . (A) Time record of [C a^{2 +} ] _myo transient in the control case as well as with 3 mM [C a^{2 +} ] _o and 1 μ M ISO. (B) Traces for normalized force recorded at steady state with an overlay of [C a^{2 +} ] _myo transient. (C) Phase plots of normalized force versus the instantaneous C a^{2 +} concentration in the cytosol with an overlay of traces showing normalized steady state force versus [C a^{2 +} ] _myo relationship. Model generated data corresponds to an idealized rat ventricular myocyte at 22.5°C.