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Figure 5 | Theoretical Biology and Medical Modelling

Figure 5

From: Multiphysics model of a rat ventricular myocyte: A voltage-clamp study

Figure 5

Isometric contraction. Twitch response - Isometric contraction. The cell is held at a constant total length but the sarcomere is allowed to contract via a series elastic element. (A) Steady state F-Ca relationships for increasing KSE values. (B) Traces for total muscle force during an isometric twitch with KSE values of 1(∙), 1.4, 2, 3, 4, 5, 7, 10 and 50 (∗) where units of KSE are normalized force-per-micrometer extension. (C) phase plots of self normalized force versus [C a2 + ] myo for increasing KSE values (corresponding to panel B) overlayed with two steady state F-Ca relationships corresponding to KSE = 1.0 (∙) and 50.0 (∗). (D) Sarcomere length traces showing internal shortening. Model generated data corresponds to an idealized rat ventricular myocyte at 22.5°C.

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