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Figure 8 | Theoretical Biology and Medical Modelling

Figure 8

From: Multiphysics model of a rat ventricular myocyte: A voltage-clamp study

Figure 8

Regulation of contraction via NCX. Regulation of isometric cell contraction by N a+ /C a2 + exchange. The protocol used for the isometric contraction is stimulation at 5 Hz comprising of 30 beats when the cell undergoes unperturbed contraction (phase A) followed by 30 beats (phase B) when the N a+ /C a2 + exchanger function is partially inhibited after which the inhibition is relieved allowing the cell to recover to a steady state control during the following 30 beats (phase C). (A) The N a+ /C a2 + exchanger current (I NaCa ) showed a rapid transition between the control and inhibited phase and vice versa. (B) Relative role of the N a+ /C a2 + exchanger and the SERCA pump. (C) Myoplasmic C a2 + concentration. (D) Sarcomere length in response to I NaCa inhibition. Model generated data corresponds to an idealized rat ventricular myocyte at 22.5°C.

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