A hunter virus that targets both infected cells and HIV free virions: Implications for therapy

Table 3 Parameter sensitivities

Parameter	Parameter change from default ± 50%	% Recovery of healthy cells at low HIV turnover	% Recovery of healthy cells at high HIV turnover
Default	0	71	52
i _v	+	61	42
i _v	–	80	69
p _v:v	+	62	45
p _v:v	–	78	63
p _v:vw	+	71	49
p _v:vw	–	70	55
r _v	+	74	61
r _v	–	67	40
d _v	+	72	52
d _v	–	71	52
n	+	71	51
n	–	68	53
i _w	+	76 (+5)	58 (+6)
i _w	–	55	37
p _w	+	79 (+8)	61 (+9)
p _w	–	47	35
r _w	+	59	43
r _w	–	83 (+12)	66 (+14)
d _vw	+	64	44
d _vw	–	77 (+6)	57 (+5)
p _s	+	74 (+3)	54 (+2)
p _s	–	66	49
i _s:v	+	71	52
i _s:v	–	71	52
i _s:w	+	71	52
i _s:w	–	71	52
r _s	+	70	52
r _s	–	71	52
d _s	+	66	51
	–	79 (+8)	55 (+3)

The percent of healthy CD4⁺ cell recovery caused by changing model parameters values at low (default) and high (10×default) HIV turnover values. Results were similar for different initial values of the variables. Note: The parameters p_h and d_h were not tested for sensitivity because they define the base healthy CD4⁺ cell concentration of 200 cells/μL to which all other results are compared. Parenthesis indicates the additional recovery in relation to default for hunter related parameters.

ISSN: 1742-4682