Figure 10
From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
Liver GSH depletion and recovery. The black, blue, magenta, green, and red curves show liver GSH depletion and recovery after a therapeutic dose (1 g) of APAP, and after 5 g, 10 g, 15g, and 20 g doses, respectively. Liver GSH is almost completely depleted between 2 hours and 10 hours after the 15 gram dose and after 48 hours liver GSH has recovered only to about 1/2 of normal. Even for the therapeutic dose, liver GSH has not completely recovered after 48 hours.