Liver reaction velocities as function of dose. Panel A shows the sum of the rates of the glucoronidation reactions in the liver 0.5 hours after the dose for a range of doses. The normal dose is 20 mg/kg assuming a 60 kg individual. Similarly, Panels B and C show the rates of the sulfation reaction and the sum of the P450 reactions, respectively. The sulfation reaction saturates at relatively modest doses.