Skip to main content
Figure 7 | Theoretical Biology and Medical Modelling

Figure 7

From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

Figure 7

Glutathione depletion and hepatic necrosis under chronic therapeutic dosing. Panels A, B, and C show the model computations liver GSH, plasma GSH, and liver necrosis as a result of therapeutic dosing of APAP(1 gram every 6 hours) for 10 days. The curves reach their new steady states after about 150 hours. The curves oscillate because of the period dosing of APAP, the resynthesis of GSH in the liver, and regeneration of cells in the liver.

Back to article page