Figure 8

The effects of APAP dose and CYP activity on covalent binding and necrosis. Panel A: Model computations show the effect of P450 activity on liver necrosis at 12 hours after APAP doses of various sizes (normal, green; twice normal, blue; four times normal, red). Liver failure is thought to occur when the percent of functional hepatocytes falls below 30%[10]. Panel B: Model computations of the effect of of P450 activity on the covalent binding of NAPQI at 12 hours after APAP doses of various sizes (normal, green; twice normal, blue; four times normal, red). For relatively modest doses, P450 activity has little effect in both cases. However, the effect of P450 activity is dramatic for high doses.