Table 2 Parameters ( μ M, μ M/hr,/hr)
From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
| Parameter | Value | Parameter Description |
|---|---|---|
| Compartment volumes (liters) | ||
| vG | 1 | gut |
| vP | 3 | plasma |
| vL | 1.5 | liver |
| vT | 30 | tissue |
| vU | 1.5 | urine |
| Transport parameters (μ M/hr) | ||
| k gl | 4 | APAP from gut to liver |
| k pt | 0.39 | APAP from plasma to tissue |
| k tp | 0.78 | APAP from tissue to plasma |
| k pl | 0.0225 | APAP from plasma to liver |
| k lp | 0.2025 | APAP from liver to plasma |
| k slp | 0.24 | sulfonate from liver to plasma |
| k stp | 0.0913 | sulfonate from tissue to plasma |
| k glp | 0.3024 | glucoronidate from liver to plasma |
| k gtp | 0.5171 | glucoronidate from tissue to plasma |
| k nqglp | 0.3 | NAPQI-GSH conjugate from liver to plasma |
| k pu | 0.06 | APAP from plasma to urine |
| k spu | 4 | sulfonate from plasma to urine |
| k gpu | 3.8 | glucoronidate from pasma to urine |
| k nqgpu | 0.4 | NAPQI-GSH conjugate from plasma to urine |
| k u | 1.54 | urine elimination |
| Hepatocyte parameters | ||
| r | .0417 | logistic growth (h r−1) |
| h max | (1. 6)1011 | maximum hepatocyte number |
| η | (. 213)10−4. 2 | cell death rate due to NAPQI (h r−1μ M−1) |
| δ z | .2083 | removal of dead hepatocytes (h r−1) |