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Table 2 Parameters ( μ M, μ M/hr,/hr)

From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

Parameter

Value

Parameter Description

Compartment volumes (liters)

  

vG

1

gut

vP

3

plasma

vL

1.5

liver

vT

30

tissue

vU

1.5

urine

Transport parameters (μ M/hr)

  

k gl

4

APAP from gut to liver

k pt

0.39

APAP from plasma to tissue

k tp

0.78

APAP from tissue to plasma

k pl

0.0225

APAP from plasma to liver

k lp

0.2025

APAP from liver to plasma

k slp

0.24

sulfonate from liver to plasma

k stp

0.0913

sulfonate from tissue to plasma

k glp

0.3024

glucoronidate from liver to plasma

k gtp

0.5171

glucoronidate from tissue to plasma

k nqglp

0.3

NAPQI-GSH conjugate from liver to plasma

k pu

0.06

APAP from plasma to urine

k spu

4

sulfonate from plasma to urine

k gpu

3.8

glucoronidate from pasma to urine

k nqgpu

0.4

NAPQI-GSH conjugate from plasma to urine

k u

1.54

urine elimination

Hepatocyte parameters

  

r

.0417

logistic growth (h r−1)

h max

(1. 6)1011

maximum hepatocyte number

η

(. 213)10−4. 2

cell death rate due to NAPQI (h r−1μ M−1)

δ z

.2083

removal of dead hepatocytes (h r−1)