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Table 2 Parameters ( μ M, μ M/hr,/hr)

From: The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

Parameter Value Parameter Description
Compartment volumes (liters)   
vG 1 gut
vP 3 plasma
vL 1.5 liver
vT 30 tissue
vU 1.5 urine
Transport parameters (μ M/hr)   
k gl 4 APAP from gut to liver
k pt 0.39 APAP from plasma to tissue
k tp 0.78 APAP from tissue to plasma
k pl 0.0225 APAP from plasma to liver
k lp 0.2025 APAP from liver to plasma
k slp 0.24 sulfonate from liver to plasma
k stp 0.0913 sulfonate from tissue to plasma
k glp 0.3024 glucoronidate from liver to plasma
k gtp 0.5171 glucoronidate from tissue to plasma
k nqglp 0.3 NAPQI-GSH conjugate from liver to plasma
k pu 0.06 APAP from plasma to urine
k spu 4 sulfonate from plasma to urine
k gpu 3.8 glucoronidate from pasma to urine
k nqgpu 0.4 NAPQI-GSH conjugate from plasma to urine
k u 1.54 urine elimination
Hepatocyte parameters   
r .0417 logistic growth (h r−1)
h max (1. 6)1011 maximum hepatocyte number
η (. 213)10−4. 2 cell death rate due to NAPQI (h r−1μ M−1)
δ z .2083 removal of dead hepatocytes (h r−1)