Table 3 Biochemical Parameters ( μ M, μ M/hr,/hr)

V _CYP

p

20

d

18000

n

2

V _CYP1A2

cytochrome CYP1A2

K _m

3430

3430-3440

[16]

V _max

0.55

V _CYP2E1

cytochrome CYP2E1

K _m

677

677-1260

[16]

V _max

345

V _CYP3A4

cytochrome CYP3A4

K _m

276

276-313

[16]

V _max

0.99

V _(l/t)SULT

sulfation

$K_m^{\mathit{\text{apap}}}$

97

97

[24]

$K_m^{\mathit{\text{paps}}}$

5.6

5.6

[25]

V _max in liver

1785

V _max in tissue

357

PAPS metabolism

V _lpaps (synthesis liver)

0.1

k _lpaps (linear removal)

0.0033

V _tpaps (synthesis tissue)

0.01

k _tpaps (linear removal)

0.00033

V _GST

glutathione transferase

$K_m^{\mathit{\text{GSH}}}$

5200

4600–5600

[21, 22]

$K_m^{\mathit{\text{NAPQI}}}$

15

V _max

72000

covalent binding

k _bind

1000

k _rev

0.25

V_(l/t)UGT=V_UGT1 + V_UGT2 + V_UGT3 + V_UGT4

V _UGT1

glucoronidation

K _m

5500

5500

[20]

n (Hill)

3.2

V _max in liver

6370

V _max in tissue

1274

V _UGT2

glucoronidation

K _m

4000

4000

[20]

K _i

23000

23000

[20]

V _max in liver

490

V _max in tissue

98

V _UGT3

glucoronidation

K _m

9200

9200

[20]

V _max in liver

4900

V _max in tissue

980

V _UGT4

glucoronidation

K _m

23000

23000

[20]

K _i

5300

5300

[20]

V _max in liver

7350

V _max in tissue

1470