Table 1 Co-infection within-host model parameter values
Parameter | Value | Reference |
|---|---|---|
Rate of red blood cell production (Δ) | 2.5 × 108 cells/ml day | |
Natural death rate of uninfected red blood cells (μ x ) | 0.0083/day | |
Infection rate of red blood cells by merozoites (k m ) | 2.5 × 10-10/merozoite day | |
Differentiation rate of merozoite (μ 1 ) | 0.5/day | |
Natural death rate of infected blood cells (μ y ) | 0.025/day | |
Clearance rate of infected red blood cells due to the immune system (μ c ) | 1 × 10-8/cell day | [50] |
Natural death rate of free merozoites (μ m ) | 48/day | |
Death rate of merozoites by contact with immune cells (μ h ) | 1 × 10-8/cell day | |
Merozoite production per infected red blood cell (r) | 16 | |
Production rate of immune cells (malaria specific) (ε) | 1 × 10-4 cell/ml day | [47] |
Proliferation rate of immune cells in response to infected red blood cells (λ y ) | 2 × 10-8/cell day | [50] |
Proliferation rate of immune cells in response to merozoites (λ m ) | 3 × 10-8/merozoite day | [50] |
Maximum number of activated immune cells per ml of blood (T max ) | 1.5 × 106 cell/ml | [58] |
HIV infection rate for nonspecific immune cell (k v ) | [0.1 × 10-5 - 2 × 10-5] virion/day | Representative values |
Production rate of immune cells (s) | 1 × 104 cell/ml day | [38] |
Growth rate of non-specific immune cells (r T ) | 0.03/day | [80] |
Natural death rate of immune cells (d t ) | 0.01/day | [81] |
Death rate of HIV infected cells (δ) | 0.7/day | [58] |
HIV production by an infected cell (N) | [20-300] virions/cell | Representative values |
HIV removal rate (c) | 23/day | [82] |