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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: A control system analysis of the dynamic response of N-methyl-D-aspartate glutamate receptors to alcoholism and alcohol withdrawal

Figure 2

Steady state controller actions for various primary parameter alterations. The number of NMDARs translocated to the synapse per hour by each controller with various values of y max (A), n (B), and a (C). In each panel, the action of the activity controller is positive, changing in response to ΔU, whereas the action of the density controller is negative and changes according to ΔT. Parameter values were altered in common intervals across both controllers. For (A), y max  = 5 (red), 10 (orange), 15 (yellow), 20 (green), 25 (blue), and 30 (purple) receptors/hour. For (B), n = 1 (red), 2 (orange), 3 (yellow), 4 (green), 5 (blue), and 6 (purple). For (C), a = 25 (red), 50 (orange), 75 (yellow), 100 (green), 125 (blue), and 150 (purple) receptors. Parameter values not explicitly changed are those of Parameter Set A. Increased alcohol concentration decreases the value of a 1 , as shown by the open arrow in (C).

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