Figure 3

The magnitude and duration of predicted excitotoxicity varies with controller configuration. In response to the alcohol input of Equation 15 (shown in Figure 1A), the number of blocked (blue) and unblocked (red) NMDARs at the synapse varies with controller configuration. Controller parameters are listed in Table 1: (A) Parameter Set B, (B) Parameter Set C, (C) Parameter Set D, (D) Parameter Set E. Excitotoxicity is inferred when the number of unblocked receptors at the synapse is greater than 100 (the arbitrarily defined explicit set point).