Table 1 Pharmacokinetic parameters of scBsAb with different interchain linker
scBsAb | Fitted equation | T1/2α | T1/2β | Goodness of fit |
|---|---|---|---|---|
(min) | (min) | (R2) | ||
125I -(Fc) scBsAb | y = 8.67e−0.0041t + 4.75e−0.005t | 16.1 | 168.7 | 0.998 |
125I -(205C’) scBsAb | y = 1.86e−0.0038t + 4.75e−0.0061t | 17.4 | 119.5 | 0.995 |
125I -(HSA) scBsAb | y = 14.12e−0.0432t + 2.89e−0.0035t | 17.2 | 264.2 | 0.999 |