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Table 1 Pharmacokinetic parameters of scBsAb with different interchain linker

From: Effects of different interchain linkers on biological activity of an anti-prostate cancer single-chain bispecific antibody

scBsAb Fitted equation T1/2α T1/2β Goodness of fit
(min) (min) (R2)
125I -(Fc) scBsAb y = 8.67e−0.0041t + 4.75e−0.005t 16.1 168.7 0.998
125I -(205C’) scBsAb y = 1.86e−0.0038t + 4.75e−0.0061t 17.4 119.5 0.995
125I -(HSA) scBsAb y = 14.12e−0.0432t + 2.89e−0.0035t 17.2 264.2 0.999