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Fig. 6 | Theoretical Biology and Medical Modelling

Fig. 6

From: Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

Fig. 6

FA and normal cells co-express checkpoint and CHKREC proteins. a Western Blot analysis of checkpoint proteins. b Western blot analysis of CHKREC proteins. FA cells increase the amount of some G2 blockage proteins, but have a reduction in others. Although CHK1 (Fig. 4 b) and MYT1 show increased signal, WEE1, γH2AX and p21 protein appear as diminished in FA cells, this weakens the checkpoint blockage, which is eventually overwhelmed by CHKREC signaling (n = 3 independent experiments, see also Fig.7)

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682