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Fig. 8 | Theoretical Biology and Medical Modelling

Fig. 8

From: Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

Fig. 8

CHKREC components activation in normal and FA cells. After DNA damage induction, the cell activates the DNA damage integrity checkpoints, the G2/M checkpoint specifically avoids the transition of the cell from G2 to M phase with unrepaired DNA damage. Once the DNA has been repaired, the G2/M checkpoint is satisfied and the cell activates the CHKREC, a process that inactivates checkpoint proteins and promotes cell division. Upper panel. Normal cells activate CHKREC with repaired chromosomes. Bottom panel. FA cells activate CHKREC despite unrepaired chromosomes. The specific mechanism triggering this inappropriate CHKREC activation in FA cells remains unknown

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682