Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process

Table 2 Network model simplification criteria

Node in the	Nodes in the	Simplification criteria
original BNM	simplified BNM
ICL	ICL	Unchanged node
FANCM, FAcore	FAcore	ICL recognition proteins working
		together in the upstream FA/BRCA
		pathway
FANCD2I	FANCD2I	Unchanged node
MUS81	NUC1	Nuclease mediated
		ICL incision
XPF, FAN1	NUC2	Nuclease mediated
		ICL incision
ADD	ADD	Unchanged node
DSB	DSB	Unchanged node
ATR, CHK1, H2AX	ATR	These proteins act in the
		Checkpoint pathway
ATM, CHK2, H2AX	ATM	These proteins act in the
		Checkpoint pathway
p53	p53	Unchanged node
PCNATLS	TLS	This is only a change in name
FANCJMLH1, MRN, BRCA1,	FAHRR	These proteins act in the
FANCD1N, RAD51, HRR,		Homologous Recombination
ssDNARPA		Repair pathway
——	HRR2	New node representing the
		alternative Homologous
		Recombination Repair Pathway
KU, DNAPK, NHEJ	NHEJ	These proteins act in the
		Non-Homologous End-Joining
		DNA repair pathway
USP1, CHKREC	CHKREC	Global negative regulators
		of the FA/BRCA pathway

ISSN: 1742-4682