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Table 1 Estimates of the energetic costs of cancer and comparable tissues

From: Modeling the energetic cost of cancer as a result of altered energy metabolism: implications for cachexia

Organ K aerobic (kcal/kg/day) K anaerobic (kcal/kg/day) K cancer or K organ (kcal/kg/day) K Cori (kcal/kg/day) K cost (kcal/kg/day)
Cancer: Study A [35] 150 ± 55 50 ± 18 200 ± 73 150 ± 55 300 ± 110
Cancer: Study B [32] 200 to 230 50 to 80 270 to 310 200 to 230 400 to 470
Liver [39] 200 0 200 0 200
Heart [39] 440 0 440 0 440
Kidney [39] 440 0 440 0 440
Brain [39] 240 0 240 0 240
Skeletal muscle [39] 13 0 13 0 13
  1. The specific energetic cost of cancer, with X anaerobic  = 25 %, are compared with various other organs. Typical organs are assumed to have complete oxidation. Cost is rounded to two significant figures. Study A was a study of n = 18 metastatic colorectal cancer patients [35]. Study B was a study of n = 85 cancer patients studied preoperatively, with a majority of patients having solid tumors of the gastrointestinal tract, retroperitoneum, or limbs [32]. Ranges of cost were given due to patient mass in the studies not being provided. Details of calculations involved in K cost for Study B are detailed in Additional file 3, and were based on the plot of oxygen consumption of patients and their tumor bulk with r2 = 0.79. Estimates of energetic costs of cancer should be taken with caution, as they could be highly variable due to the type of cancer studied