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Table 1 Average corrected waiting times for a string of five nucleotides

From: The waiting time problem in a model hominin population

Mutation rate per string per generation

Average number of instances before fixation

Average corrected waiting time to 1st instance (yrs)

Average corrected waiting time to effective instance (yrs)

Average duration of amplification (yrs)

Total average corrected waiting time (yrs)

95 % Confidence Interval for total waiting time (yrs)

0.01

15.6

1.05 × 109

1.72 × 109

1.80 × 104

1.72 × 109

2.46 × 108

0.001

9.0

1.70 × 109

2.31 × 109

1.44 × 104

2.31 × 109

4.98 × 108

0.0001

8.7

4.43 × 109

6.10 × 109

1.60 × 104

6.10 × 109

2.39 × 109

0.00001

7.6

8.53 × 109

1.11 × 1010

1.67 × 104

1.11 × 1010

3.42 × 109

0.0000001 biological rate

    

3.95 × 10 10 (extrapolated)

 
  1. The correction factor was proportional to the mutation rate enhancement, but was not applied to duration of the amplification phase. Each data point is the mean of 25 replicates. Population size (10,000) and beneficial fitness effect (10 %) were held constant. Mutation rates and correction factors range over four orders of magnitude. The last row (in italics) reflects the true mutation rate, which requires computational resources not presently available. This last data point is derived by extrapolation using the equation based on the line of best fit in Fig. 1
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682