Fig. 3

Network visualization of the BEL mechanistic model for causal mutations in PINK1. The model represents the causal association of upstream variants of PINK1 (highlighted in yellow) with downstream pathways and biological processes (highlighted in red). Genes are shown in cyan, intermediary processes in blue, translocation in grey, and reactive oxygen species in green. Relationships have been represented as increase (delta-shaped arrows), decrease (T-shaped arrows), association (diamond-shaped arrows) or variation (circle-shaped arrows). Direct effects have been shown by ‘increase’ or ‘decrease’ annotations on edges whereas indirect effects with unknown intermediate steps are represented by ‘association’ and ‘positive/negative correlation’ relations. Moreover, activation effect of one molecule on another is shown with ‘acts in’, translocation process is annotated with ‘translocates’, and phosphorylation processes have been represented by ‘has_Modification’