Table 2 Parameter values and the final value of the knowledge gain calculated for three major branches of PDON. TM: number of relevant genes/proteins to the branch by PDON; GS: number of genes/proteins extracted from the PD map as gold standard; N: total number of genes/proteins for each branch retrieved by PDON. The queries were performed on Human Genes/Proteins and SCAIView returned lists of unique genes specific to each branch. Numbers represent counts of retrieved genes by SCAIView using PDON
Knowledge domain branches | TM | TM ∩ GS | NTM | Gain of novel knowledge | Enriched pathways in the content of new knowledge |
|---|---|---|---|---|---|
Etiology of PD | 173 | 82 | 273 | 33 % | MAPK, Chemokine, Adipocytokine, Neurotrophin, Insulin signaling |
Clinical aspects of PD | 286 | 97 | 683 | 27 % | GPCR signaling, Neuroactive ligand-receptor interactions, Rhodopsin-like receptors, Peptide ligand-binding receptors, Gastrin-CREB signaling |
Neuropathology of PD | 252 | 91 | 471 | 34 % | Immune system, Signaling by GPCR, Endocytosis, Toll-like receptor signaling, Hemostasis |