Fig. 3

Simulations demonstrating bistability in two mammalian models. We searched for voltage bistability in X + Y + leak mammalian models (10:10:1 maximal conductance ratio) by simulation. Two such channel combinations uncovered by this search were the a Kv1.1 + Nav1.6 + leak and b HCN1 + Nav1.6 + leak models. As before, simulations were initialized at 30 voltages ranging from −140 to 150 mV and clamped for 50 ms before release. In both of these models, voltages initialized in the physiological range converge on one of two locally stable voltages