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Table 1 Set of functions for the Boolean model of gonadal sex determination

From: A Boolean network model of human gonadal sex determination

UGR, UGR & ! (NR5A1 WNT4)

CBX2, UGR & ! (NR0B1 & WNT4 & CTNNB1)

GATA4, (UGR WNT4 NR5A1 SRY)

WT1mKTS, (UGR GATA4)

WT1pKTS, (UGR GATA4) & ! (WNT4 & CTNNB1)

NR5A1, (UGR CBX2 WT1mKTS GATA4) & ! (NR0B1 & WNT4)

NR0B1, (WT1mKTS (WNT4 & CTNNB1)) & ! (NR5A1 & SOX9)

SRY, ((NR5A1 & WT1mKTS & CBX2) (GATA4 & WT1pKTS & CBX2 & NR5A1) (SOX9 SRY)) & ! (CTNNB1)

SOX9, ((SOX9 & FGF9) (SRY PGD2) (SRY & CBX2) (GATA4 & NR5A1 & SRY)) & ! (WNT4 CTNNB1 FOXL2)

FGF9, SOX9 & ! WNT4

PGD2, SOX9

DMRT1, (SRY SOX9) & ! (FOXL2)

DHH, SOX9

DKK1, (SRY SOX9)

AMH, ((SOX9 & GATA4 & NR5A1) (SOX9 & NR5A1 & GATA4 & WT1mKTS)) & ! (NR0B1 & CTNNB1)

WNT4, (GATA4 (CTNNB1 RSPO1 NR0B1)) & ! (FGF9 DKK1)

RSPO1, (WNT4 CTNNB1) & ! (DKK1)

FOXL2, (WNT4 & CTNNB1) & ! (DMRT1 SOX9)

CTNNB1, (WNT4 RSPO1) & ! (SRY (SOX9 & AMH))