Parameter\Case

Unit

Control

1000

2000

3000

4000


α

Gy^{−1}
 
0.30

0.20

0.16

0.145

Dose

Gy
 
10

20

30

40

T_{d}(0)

days

1.35

1.35

1.35

1.35

1.35

θ
 
0.72

0.72

0.74

0.795

0.838

T_{cl}

days
 
4

4

4

4

N
 
11

11

19

18

14

MSD^{b}
 
0.01883

0.01099

0.00816

0.00832

0.03039

AIC^{c}
 
−59.76

−66.00

−137.31

−128.23

−75.86

S^{d}
 
1.00E + 00

9.83E01

2.84E01

5.38E02

4.51E03


^{a}Initial volume = 0.0157 cm^{3}. The radiation was turned on at the 11^{th} day. The following model parameters were set constant: α/β = 10 Gy, active radiationeffect time τ_{rad} = 8 days, cell cycle time T_{cc} = 1 day, colony counting time T_{m} = 10 days

^{b}Mean square of difference between the experimental data and the model estimated volumes

^{c}AIC defined by Eq.(33) with k = 5. The number of data points, N, is shown in the table

^{d}S is the fraction of surviving cells after irradiation. It is not a parameter used in the simulation model. But, it is included in this table to show the degree of cell kill by radiation. See the text for details