Parameter\Case
|
Unit
|
Control
|
1000
|
2000
|
3000
|
4000
|
---|
α
|
Gy−1
| |
0.30
|
0.20
|
0.16
|
0.145
|
Dose
|
Gy
| |
10
|
20
|
30
|
40
|
Td(0)
|
days
|
1.35
|
1.35
|
1.35
|
1.35
|
1.35
|
θ
| |
0.72
|
0.72
|
0.74
|
0.795
|
0.838
|
Tcl
|
days
| |
4
|
4
|
4
|
4
|
N
| |
11
|
11
|
19
|
18
|
14
|
MSDb
| |
0.01883
|
0.01099
|
0.00816
|
0.00832
|
0.03039
|
AICc
| |
−59.76
|
−66.00
|
−137.31
|
−128.23
|
−75.86
|
Sd
| |
1.00E + 00
|
9.83E-01
|
2.84E-01
|
5.38E-02
|
4.51E-03
|
-
aInitial volume = 0.0157 cm3. The radiation was turned on at the 11th day. The following model parameters were set constant: α/β = 10 Gy, active radiation-effect time τrad = 8 days, cell cycle time Tcc = 1 day, colony counting time Tm = 10 days
-
bMean square of difference between the experimental data and the model estimated volumes
-
cAIC defined by Eq.(33) with k = 5. The number of data points, N, is shown in the table
-
dS is the fraction of surviving cells after irradiation. It is not a parameter used in the simulation model. But, it is included in this table to show the degree of cell kill by radiation. See the text for details