Table 3 Model parameters for radiation response: clinical GKSRS casesa
From: A mathematical model of tumor growth and its response to single irradiation
| Â | Â | Clinical case number | ||||
|---|---|---|---|---|---|---|
Parameters | Unit | 1 | 2 | 3 | 4 | 5 |
α | 1/Gy | 0.09 | 0.19 | 0.19 | 0.1 | 0.05 |
Tumor doubling time T d (0) | days | 29.0 | 6.0 | 9.0 | 6.6 | 7.8 |
Cell clearance time T cl | days | 13.0 | 38.0 | 40.0 | 10.0 | 20.0 |
Retardation factor θ | No dim. | 0.62 | 0.77 | 0.53 | 0.78 | 0.99 |
Mean dose | Gy | 38.3 | 21.2 | 26.0 | 22.0 | 24.3 |
Initial volume | cm^3 | 0.126 | 0.0065 | 0.271 | 0.031 | 0.101 |
Irradiation day for GKSRS | day | 34 | 117 | 22 | 78 | 29 |
Tumor volume at GKSRS | cm^3 | 0.268 | 0.392 | 0.662 | 6.933 | 1.314 |
Tumor doubling time at GKSRS | days | 32.6 | 28.0 | 11.2 | 16.1 | 7.9 |
Volume ratio, R40 b | Â | 0.16 | 0.57 | 0.58 | 0.69 | 10.0 |
% Cell survival fraction | Â | 2.24 | 6.03 | 1.99 | 25.4 | 70.0 |