Skip to main content

Table 3 Model parameters for radiation response: clinical GKSRS casesa

From: A mathematical model of tumor growth and its response to single irradiation

   Clinical case number
Parameters Unit 1 2 3 4 5
α 1/Gy 0.09 0.19 0.19 0.1 0.05
Tumor doubling time T d (0) days 29.0 6.0 9.0 6.6 7.8
Cell clearance time T cl days 13.0 38.0 40.0 10.0 20.0
Retardation factor θ No dim. 0.62 0.77 0.53 0.78 0.99
Mean dose Gy 38.3 21.2 26.0 22.0 24.3
Initial volume cm^3 0.126 0.0065 0.271 0.031 0.101
Irradiation day for GKSRS day 34 117 22 78 29
Tumor volume at GKSRS cm^3 0.268 0.392 0.662 6.933 1.314
Tumor doubling time at GKSRS days 32.6 28.0 11.2 16.1 7.9
Volume ratio, R40 b   0.16 0.57 0.58 0.69 10.0
% Cell survival fraction   2.24 6.03 1.99 25.4 70.0
  1. aIn all cases, α/β = 10, τ rad  = 8 days, TCC = 1 day, and Tm = 10 days
  2. bR40 = the ration of the volume on the 40th day after GKSRS and the volume at GKSRS