From: The role of mobility and health disparities on the transmission dynamics of Tuberculosis
Nomenclature | |
---|---|
Risk | Interpreted based on levels of infection rate, prevalence, |
or average contacts (via population size) | |
High-risk patch | Defined either by high direct first time infection rate (i.e., high β |
which leads to high corresponding \(\mathcal {R}_{0}\)) or by high exogenous re-infection rate | |
(i.e., high δ) | |
Enhanced socio-economic conditions (reducing health disparity) | Defined by better healthcare infrastructure which is incorporated by high prevalence of a disease (i.e., high I(0)/N) in a large population (i.e., large N) |
Mobility | Captured by average residence times of an individual in different patches (i.e., by using \(\mathbb {P}\) matrix) |
Scenarios (assume high-risk and enhanced socio-economic conditions in Patch 1 as compared to Patch 2) | |
Scenario 1 | \(\underbrace {\beta _{1} > \beta _{2}, \ \delta _{1} = \delta _{2}}_{\text {high risk}}\); \(\underbrace {\frac {I_{1}(0)}{N_{1}} > \frac {I_{2}(0)}{N_{2}}, \ N_{1} > N_{2};}_{\text {enhanced socio-economic conditions}}\) \(\underbrace {\text {vary} \ p_{12} \ \text {when} \ p_{21}\approx 0}_{\text {mobility}}\) |
Scenario 2 | \(\underbrace {\beta _{1} = \beta _{2}, \ \delta _{1} > \delta _{2}}_{\text {high risk}}\); \(\underbrace {\frac {I_{1}(0)}{N_{1}} > \frac {I_{2}(0)}{N_{2}}, \ N_{1} > N_{2};}_{\text {enhanced socio-economic conditions}}\) \(\underbrace {\text {vary} \ p_{12}\ \text {when} \ p_{21}\approx 0}_{\text {mobility}}\) |