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Fig. 2 | Theoretical Biology and Medical Modelling

Fig. 2

From: Modeling multi-mutation and drug resistance: analysis of some case studies

Fig. 2

Dynamic of Cells under Different Therapeutic Strategies. This figure expresses the evaluation patterns of normal cells (black line), Wild tumor cells that are responsive to the drug (orange line), Mutated tumor cells which can potentially convert to drug-resistant tumor cells while responsive to the drug (blue line), and drug-resistant tumor cells (red line). a: Under the first therapeutic approach, it is assumed that the drug is administered at t = 50 days. The amount of the drug and the killing rates are considered to be constant. It is also considered that as the drug is introduced, the mutation to the second group of tumor cells, TM, starts immediately at the rate of 10−3 per day. Distinct from the a, in the simulation b, it is assumed that the transformation of the mutated tumor cells to resistant cells starts at the later time of t = 150 days. In c, the therapy with anti-cancer drug starts at t = 50 days. However, the amount of the drug will not stay constant and decreases exponentially over time, with a decay factor of 10−3 day−1. The simulation d evaluates the case when the system expresses an intrinsic drug resistance, in addition to an induced drug resistance with the mutation rate of wild tumor cells to drug-resistant tumor cells of 10−4 per day

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