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Fig. 3 | Theoretical Biology and Medical Modelling

Fig. 3

From: A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture

Fig. 3

Dynamics of infectious virus for SHIV-KS661 and -#64 in HSC-F cells. The distributions of the total viral burst size (RNA copies), p RNA /δ, and the infectious burst size (TCID50), p 50/δ, that were calculated from the estimated parameter distributions are shown in (a) and (b), respectively, for SHIV-KS661 (red) and -#64 (blue) strains. The time-course of the infectious viral load as a proportion of the total viral load are calculated in (c). The shadow regions correspond to 95% posterior predictive intervals, the solid and dashed curves give the best-fit solution (mean) for V 50(t)/ V RNA (t) to the time-course datasets. The pink (solid curve and round points) and red (dashed curve and triangular points) colors correspond to 2.0 × 10−4 and 2.0 × 10−5 MOI of SHIV-KS661, while the light blue (solid curve and round points) and blue (dashed curve and triangular points) colors correspond to 2.0 × 10−4 and 2.0 × 10−5 MOI of SHIV-#64, respectively

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