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Table 2 Dependence of agrochemical mixture effect predictions on Hill parameters

From: Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures

  Slope γ=1 Slope γ variable
Ligand X 50 a RMSEb X 50 a Slope RMSEb
Atrazine 0.057   0.059 0.96  
Alachlor 0.082   0.076 1.45  
Atrazine + Alachlor   9    9
Aldrin 0.008   0.010 2.20  
Dieldrin 0.004   0.005 1.95  
Aldrin + Dieldrin   10    8
Oxadixyl 18   19 1.37  
Mancozeb 294   293 0.99  
Oxadixyl + Mancozeb   25    26
  1. All pesticides are assumed to achieve individual maximum effects of 100%. The magnitude of the deviations of mixture predictions from the experimental data is an indication of synergistic effects
  2. a LC 50 (in kg/ha) for herbicides, LD 50 (in g a.i./100 ml kerosene solution) for insecticides, EC 50 (in mg/l) for fungicides;
  3. broot-mean-square error of efficacy prediction for mixture