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Table 3 AhR agonist parameters from GCA- and Hill-fits for mixture predictions

From: Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures

  GCA, γ=1 [38] Hill, γ variable
Ligand E max (%) EC 50(M) MWa E max (%) EC 50(M) γ MWa
TCDFb 100 2.9×10−11   100 3.2×10−11 0.88  
PCB126c 99 4.1×10−10   100 4.5×10−10 0.82  
TCDF + PCB126    0.86     0.86
TCDDd 100 7.6×10−12   100 6.3×10−12 1.29  
PCB105 61 1.4×10−6   56 9.2×10−7 1.45  
TCDD + PCB105    0.63     0.78
TCDD 100 9.9×10−12   100 8.5×10−12 1.09  
Galangin 30 4.1×10−6   35 4.7×10−6 0.79  
TCDD + Galangin    0.79     0.93
TCDD 100 9.1×10−12   100 6.5×10−12 1.22  
DIMe 8 6.6×10−6   10 8.5×10−6 1.62  
TCDD + DIM    0.65     0.44
  1. Parameters are slopes γ, maximum effects E max and EC 50 values of the agents
  2. aMW = Mann-Whitney test for mixture prediction;
  3. b2,3,7,8-tetrachlorodibenzofuran;
  4. c2,3,3’,4,4’-petachlorobiphenyl;
  5. d2,3,7,8-tetrachlorodibenz-p-dioxin;
  6. e3,3’-diindolylmethane