Table 3 AhR agonist parameters from GCA- and Hill-fits for mixture predictions
From: Theory of synergistic effects: Hill-type response surfaces as ‘null-interaction’ models for mixtures
GCA, γ=1 [38] | Hill, γ variable | ||||||
|---|---|---|---|---|---|---|---|
Ligand | E max (%) | EC 50(M) | MWa | E max (%) | EC 50(M) | γ | MWa |
TCDFb | 100 | 2.9×10−11 | 100 | 3.2×10−11 | 0.88 | ||
PCB126c | 99 | 4.1×10−10 | 100 | 4.5×10−10 | 0.82 | ||
TCDF + PCB126 | 0.86 | 0.86 | |||||
TCDDd | 100 | 7.6×10−12 | 100 | 6.3×10−12 | 1.29 | ||
PCB105 | 61 | 1.4×10−6 | 56 | 9.2×10−7 | 1.45 | ||
TCDD + PCB105 | 0.63 | 0.78 | |||||
TCDD | 100 | 9.9×10−12 | 100 | 8.5×10−12 | 1.09 | ||
Galangin | 30 | 4.1×10−6 | 35 | 4.7×10−6 | 0.79 | ||
TCDD + Galangin | 0.79 | 0.93 | |||||
TCDD | 100 | 9.1×10−12 | 100 | 6.5×10−12 | 1.22 | ||
DIMe | 8 | 6.6×10−6 | 10 | 8.5×10−6 | 1.62 | ||
TCDD + DIM | 0.65 | 0.44 | |||||