Fig. 6

Cancer as a stochastic system. Cancer is postulated to be initiated by the genetic-driven dysregulation of metabolism which is permitted to drive growth and proliferation due to the abrogation of the cell cycle restriction checkpoint and the inflammatory, survival and nutritional feedback of the TME. Therapeutic disruptions of the effectors of cancer growth dynamics are noted and qualified as potentially effective or ineffective based on the level and bandwidth of sensitivity to genomic instability