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Table 1 Parameters employed in kinetics model of intestinal stem cell differentiation

From: On the utility of a compartmental population kinetics model of intestinal epithelial stem cell proliferation and differentiation

Parameter Meaning Units
CBC Number of crypt-base columnar cells None
TAC Number of transit-amplifying cells None
AP Number of absorptive progenitor cells None
EC Number of enterocytes None
SP Number of secretory progenitor cells None
EEC Number of enteroendocrine cells None
TC Number of tuft cells None
GPP Number of goblet / Paneth progenitor cells None
GC Number of goblet cells None
PC Number of Paneth cells None
k 1 Crypt-based columnar cell to transit-amplifying cell differentiation rate day-1
k 2 Transit-amplifying cell to absorptive progenitor differentiation rate day-1
k 3 Transit-amplifying cell to secretory progenitor differentiation rate day-1
k 4 Secretory progenitor to goblet / Paneth progenitor cell differentiation rate day-1
k 5 Absorptive progenitor to enterocyte differentiation rate day-1
k 6 Secretory progenitor to enteroendocrine cell differentiation rate day-1
k 7 Secretory progenitor to tuft cell differentiation rate day-1
k 8 Goblet / Paneth progenitor to goblet cell differentiation rate day-1
k 9 Goblet / Paneth progenitor to Paneth cell differentiation rate day-1
α Crypt-based columnar cell proliferation rate day-1
β Transit-amplifying cell proliferation rate day-1
γ Absorptive progenitor cell proliferation rate day-1
δ Secretory progenitor cell proliferation rate day-1
ζ Goblet / Paneth progenitor cell proliferation rate day-1
λ 1 Loss rate of enterocytes day-1
λ 2 Loss rate of enteroendocrine cells day-1
λ 3 Loss rate of tuft cells day-1
λ 4 Loss rate of goblet cells day-1
λ 5 Loss rate of Paneth cells day-1
N Total number of cells per crypt / villus unit None
N c Total number of crypt cells per crypt / villus unit None
N v Total number of villus cells per crypt / villus unit None