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Table 1 Parameters employed in kinetics model of intestinal stem cell differentiation

From: On the utility of a compartmental population kinetics model of intestinal epithelial stem cell proliferation and differentiation

Parameter

Meaning

Units

CBC

Number of crypt-base columnar cells

None

TAC

Number of transit-amplifying cells

None

AP

Number of absorptive progenitor cells

None

EC

Number of enterocytes

None

SP

Number of secretory progenitor cells

None

EEC

Number of enteroendocrine cells

None

TC

Number of tuft cells

None

GPP

Number of goblet / Paneth progenitor cells

None

GC

Number of goblet cells

None

PC

Number of Paneth cells

None

k 1

Crypt-based columnar cell to transit-amplifying cell differentiation rate

day-1

k 2

Transit-amplifying cell to absorptive progenitor differentiation rate

day-1

k 3

Transit-amplifying cell to secretory progenitor differentiation rate

day-1

k 4

Secretory progenitor to goblet / Paneth progenitor cell differentiation rate

day-1

k 5

Absorptive progenitor to enterocyte differentiation rate

day-1

k 6

Secretory progenitor to enteroendocrine cell differentiation rate

day-1

k 7

Secretory progenitor to tuft cell differentiation rate

day-1

k 8

Goblet / Paneth progenitor to goblet cell differentiation rate

day-1

k 9

Goblet / Paneth progenitor to Paneth cell differentiation rate

day-1

α

Crypt-based columnar cell proliferation rate

day-1

β

Transit-amplifying cell proliferation rate

day-1

γ

Absorptive progenitor cell proliferation rate

day-1

δ

Secretory progenitor cell proliferation rate

day-1

ζ

Goblet / Paneth progenitor cell proliferation rate

day-1

λ 1

Loss rate of enterocytes

day-1

λ 2

Loss rate of enteroendocrine cells

day-1

λ 3

Loss rate of tuft cells

day-1

λ 4

Loss rate of goblet cells

day-1

λ 5

Loss rate of Paneth cells

day-1

N

Total number of cells per crypt / villus unit

None

N c

Total number of crypt cells per crypt / villus unit

None

N v

Total number of villus cells per crypt / villus unit

None