Skip to main content

Table 5 Values of constrained parameters in the baseline scenario

From: On the utility of a compartmental population kinetics model of intestinal epithelial stem cell proliferation and differentiation

Parameter Equivalent expression or constraint Value (day-1) Uncertainty (day-1)
k 3 \( {k}_3={k}_2\frac{\omega_s}{\omega_e}\frac{SP_{t\to \infty }}{AP_{t\to \infty }} \) 0.068 0.06
k 7 \( {k}_7={k}_6\frac{\lambda_3}{\lambda_2}\frac{TC_{t\to \infty }}{EEC_{t\to \infty }} \) 0.14 0.10
k 9 \( {k}_9={k}_8\frac{\lambda_5}{\lambda_4}\frac{PC_{t\to \infty }}{GC_{t\to \infty }} \) 0.095 0.045
β Not applicable (literature value) 1.75 0.25
γ β = γ = δ = ζ 1.75 0.25
δ β = γ = δ = ζ 1.75 0.25
ζ β = γ = δ = ζ 1.75 0.25
λ 3 λ 2 = λ 3 = λ 4 0.43673 0.00005
λ 4 λ 2 = λ 3 = λ 4 0.43673 0.00005