Table 2 Parameter Estimates, Description, Units and Source
From: A patient-specific treatment model for Graves’ hyperthyroidism
Parameter | Description | Value | Source | Units |
|---|---|---|---|---|
k 1 | Relative maximum uptake rate of MMI | 8.374×10−3 | Literature [28] | mg/(mL∗Lday) |
k 2 | Elimination rate of MMI | 3.3271 | Estimated | 1/day |
k a | Michealis-Menten constant for half maximal uptake rate of MMI | 0.358068 | Simulation | mg/L |
k 3 | Relative maximum secretion rate of FT4 | 0.119 | Calculation | pg/(mL2day) |
k d | Michealis-Menten constant for half maximal secretion rate of FT4 | 0.05 | Simulation | U/mL |
k 4 | Elimination rate of FT4 | 0.099021 | Estimated | 1/day |
k 5 | Relative growth rate of the functional size of thyroid gland | 1×106 | Simulation | mL3/(U∗day) |
N | Maximal growth ratio | 0.833 | Calculation | U/(mL2) |
k 6 | Thyroid inactivation rate constant | 0.001 | Simulation | mL/mg∗day |
k 7 | Maximal production rate of TRAb | 0.875 | Calculation | U/(mL∗day) |
k b | Inhibition rate of TRAb | 1.5 | Simulation | mg/L |
k 8 | Elimination rate of TRAb | 0.035 | Estimated | 1/day |