From: A patient-specific treatment model for Graves’ hyperthyroidism
Parameter | Description | Value | Source | Units |
---|---|---|---|---|
k _{1} | Relative maximum uptake rate of MMI | 8.374×10^{−3} | Literature [28] | mg/(mL∗Lday) |
k _{2} | Elimination rate of MMI | 3.3271 | Estimated | 1/day |
k _{ a } | Michealis-Menten constant for half maximal uptake rate of MMI | 0.358068 | Simulation | mg/L |
k _{3} | Relative maximum secretion rate of FT4 | 0.119 | Calculation | pg/(mL^{2}day) |
k _{ d } | Michealis-Menten constant for half maximal secretion rate of FT4 | 0.05 | Simulation | U/mL |
k _{4} | Elimination rate of FT4 | 0.099021 | Estimated | 1/day |
k _{5} | Relative growth rate of the functional size of thyroid gland | 1×10^{6} | Simulation | mL^{3}/(U∗day) |
N | Maximal growth ratio | 0.833 | Calculation | U/(mL^{2}) |
k _{6} | Thyroid inactivation rate constant | 0.001 | Simulation | mL/mg∗day |
k _{7} | Maximal production rate of TRAb | 0.875 | Calculation | U/(mL∗day) |
k _{ b } | Inhibition rate of TRAb | 1.5 | Simulation | mg/L |
k _{8} | Elimination rate of TRAb | 0.035 | Estimated | 1/day |