From: Outside-host phage therapy as a biological control against environmental infectious diseases
Parameter | Explanation of the parameter | Parameter values | |
---|---|---|---|
α | Virulence (Mortality of the infected hosts due to infection) | 0.1 (day−1) | in all the analysis |
β | Pathogen transmission rate to susceptible hosts from environment | 10−5 (day−1) | in all the analysis |
Λ | Pathogen release rate from infected hosts when they die | 109 | in all the analysis |
β B | Phage-resistant pathogen transmission rate to susceptible hosts from environment | 0–10−10 (day− 1) | in Fig. 3 |
0 (day− 1) | in Figs. 1, 2; Additional file 1: Figure S1; Additional file 3: Figure S2 and Additional file 4: Figure S3 | ||
Λ B | Phage-resistant pathogen release rate from infected hosts when they die | 105 | in Fig. 3 |
0 | in Figs. 1, 2; Additional file 1: Figure S1; Additional file 3: Figure S2 and Additional file 4: Figure S3 | ||
β F | Phage transmission rate to pathogens from the environment | 10−8–10− 4 (day− 1) | in Fig. 1 |
10− 7 (day− 1) | in Fig. 2 | ||
10− 3 (day− 1) | |||
0 | in Additional file 1: Figure S1 | ||
10− 9–10− 5 (day− 1) | in Additional file 3: Figure S2 | ||
Λ F | Phage burst size from infected pathogen | 100 | |
0 | in Additional file 1: Figure S1 | ||
0.0001–10 | in Additional file 3: Figure S2 | ||
r S | Susceptible host growth rate | 0.1 (day− 1) | in all the analysis |
r P | Pathogen growth rate outside-host | 3 (day−1) | in all the analysis |
r B | Phage-resistant bacteria growth rate outside-host | 3 (day−1) | in Fig. 3 |
0 (day− 1) | in Figs. 1, 2; Additional file 1: Figure S1; Additional file 3: Figure S2 and Additional file 4: Figure S3 | ||
K | Constant parameter K modifying the strength of density-dependence of the environmental growth rate | 109 | in all the analysis |
μ SI | Mortality of the susceptible and infected hosts due to other reasons than infection | 0.001 (day−1) | in all the analysis |
μ P | Pathogen mortality outside-host | 0.1 (day−1) | in all the analysis |
μ B | Phage-resistant bacteria mortality outside-host | 0.1 (day−1) | in Fig. 3 |
0 (day− 1) | in Figs. 1, 2; Additional file 1: Figure S1; Additional file 3: Figure S2 and Additional file 4: Figure S3 | ||
μ F | Phage decay rate outside-host | 0.1 (day− 1) | in Figs. 1, 2, 3; Additional file 3: Figure S2 and Additional file 4: Figure S3 |
0 (day− 1) | in Additional file 1: Figure S1 | ||
δ | Recovery of the hosts from infection | 0 (day− 1) | Figs. 1, 3; Additional file 1: Figure S1; Additional file 3: Figure S2 and Additional file 4: Figure S3 |
 |  | 0–0.8 (day− 1) | in Fig. 2 |