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Fig. 4 | Theoretical Biology and Medical Modelling

Fig. 4

From: A conceptual model for optimizing vaccine coverage to reduce vector-borne infections in the presence of antibody-dependent enhancement

Fig. 4

Zika transmission diagram showing how dengue vaccination affects the total number of Zika infections by the end of an outbreak. Through Route 1 individuals are directly infected by ZIKV without a previous dengue infection; through Added Route individuals are infected by ZIKV with a prior dengue vaccination; through Route 2 individuals are coinfected with Zika and dengue; and through Route 3 individuals are subsequently infected by ZIKV with a prior recovery from dengue infection. The width of the pink bars, based on model simulations, represent the contributions toward Zika infections from each route and the total Zika infections of the two scenarios. While the accumulated number of human infected with ZIKV could increase significantly through Route 1 and Added Route with enhanced transmission of ZIKV after dengue vaccine and due to ADE, because of the cocirculation of dengue and Zika viruses, the accumulated number of ZIKV infections can decrease significantly through Route 2 or/and Route 3 since the susceptible humans who can gain Zika through Route 2 and/or Route 3 are proportionally decreased

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