Fig. 7From: Modern and traditional approaches combined into an effective gray-box mathematical model of full-blood acid-baseThe effect of changing the albumin level in plasma. a Adding (or removing) the albumin together with its anti-charged cation equivalent (e.g., Na+) varies the the SID accordingly (bold red) and the BE and pH remain constant, which contrasts with clinical observations. b Adding (or removing) the albumin in electroneutral solution with corresponding amount of H+ maintains the SID unchanged (bold black), but the pH rises to alkalosis for hypoalbuminemia and falls to acidosis during hyperalbuminemia, which corresponds with Stewart’s theory of acute hypoalbuminemic alkalosisBack to article page