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Fig. 7 | Theoretical Biology and Medical Modelling

Fig. 7

From: Identification of influential proteins in the classical retinoic acid signaling pathway

Fig. 7

Effects of CRABP2 on transcriptional activity of RAR at various levels of RA and RAR. COS-7 cells were transfected with a luciferase reporter construct driven by a RAR responsive element, and the activity level of the reporter was measured in different conditions. (a) Luciferase activity level after adding exogenous levels of CRABP2 to the cells at various concentrations of RA. Data are presented as fold induction relative to luciferase reporter activity level before overexpression of CRABP2. Experimental data was obtained from [7]. (b) Luciferase activity level after adding exogenous levels of CRABP2 to the cells, in the presence of endogenous RAR or upon overexpression of RAR. Data are presented as fold induction relative to luciferase reporter activity level before overexpression of CRABP2. Experimental data was given from [7]. (c) Fold change in total mRNA production after increasing CRABP2 concentration by 200%. Data are normalized by total mRNA production before CRABP2 overexpression. 10,000 points were randomly sampled following a uniform distribution over a 44-dimensional parameter space, to generate this Figure. (d) Fold change in total mRNA production after increasing CRABP2 concentration by 200% in the presence of endogenous RAR or exogenous RAR, i.e. RAR = 10 μM. Data are normalized by total mRNA production before CRABP2 overexpression. 10,000 points were randomly sampled following a uniform distribution over a 44-dimensional parameter space, to generate this Figure

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