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Table 2 List of reactions in the RA signaling pathway

From: Identification of influential proteins in the classical retinoic acid signaling pathway

Number

Reaction

1

RA + CRABP1 ⇔ RA : CRABP1

2

RA + CRABP2 ⇔ RA : CRABP2

3

RA + CYP ⇔ RA : CYP

4

RA : CYP ⇒ CYP + (RA metabolites)

5

RA + RAR ⇔ RA : RAR

6

RARmRNA ⇒ RAR

7

CRABP2mRNA ⇒ CRABP2

8

CYPmRNA ⇒ CYP

9

RA : CRABP1 + CYP ⇔ RA : CRABP1 : CYP

10

RA : CRABP1 : CYP ⇒ CRABP1 : CYP + (RA metabolites)

11

RA : CRABP2 + CYP ⇔ RA : CRABP2 : CYP

12

RA : CRABP2 : CYP ⇒ CRABP2 : CYP + (RA metabolites)

13

RA : CRABP2 + RAR ⇔ RA : CRABP2 : RAR

14

RA : CRABP2 : RAR ⇒ RA : RAR + CRABP2

15

CRABP1 + CYP ⇔ CRABP1 : CYP

16

CRABP2 + CYP ⇔ CRABP2 : CYP

17

CRABP1 ⇒ ∅

18

CRABP2 ⇒ ∅

19

CYP ⇒ ∅

20

RAR ⇒ ∅

21

RA : CRABP1 ⇒ RA + ∅

22

RA : CRABP2 ⇒ RA + ∅

23

RA : RAR ⇒ RA + ∅

24

RARmRNA ⇒ ∅

25

CRABP2mRNA ⇒ ∅

26

CYPmRNA ⇒ ∅

27

CRABP1 : CYP ⇒ CYP + ∅

28

CRABP1 : CYP ⇒ CRABP1 + ∅

29

CRABP2 : CYP ⇒ CYP + ∅

30

CRABP2 : CYP ⇒ CRABP2 + ∅

  1. RA-induced expression of RAR, CRBAP2 and CYP genes are modeled using Eq. 4