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Table 3 List of the independent model parameters

From: Identification of influential proteins in the classical retinoic acid signaling pathway

Parameter Description Range Reference
CRABP1 Total concentration of CRABP1 1 nM – 10 μM Unknown. A large range is used.
CRABP2 Total concentration of CRABP2 1 nM – 10 μM Unknown. A large range is used.
CYP Total concentration of CYP 1 nM – 10 μM Unknown. A large range is used.
RAR Total concentration of RAR 1 nM – 1 μM Unknown. A large range is used.
k d3 Equilibrium dissociation constant of reaction #3 1 nM −64 nM [6]
k on13 Forward rate of reaction #13 3.6 × 109 − 3.6 × 1010 [37]
k d13 Equilibrium dissociation constant of reaction # 13 0.1 nM–10 nM [38]
k on14 Forward rate of reaction #14 50–200 1/h [5]
k on15 Forward rate of reaction #15 3.6 × 109 − 3.6 × 1010 [37]
k on16 Forward rate of reaction #16 3.6 × 109 − 3.6 × 1010 [37]
f RAR Transcription factor fraction for RAR gene 0–1 By definition
f CRABP2 Transcription factor fraction of CRABP2 gene 0–1 By definition
f CYP Transcription factor fraction for CYP gene 0–1 By definition
f GOI Transcription factor fraction for the GOI 0–1 By definition
  1. Reactions are shown in Table 2
  2. Transcription factor fractions are defined in Section “Gene expression through RA pathway