Identification of influential proteins in the classical retinoic acid signaling pathway

Table 3 List of the independent model parameters

Parameter	Description	Range	Reference
CRABP1	Total concentration of CRABP1	1 nM – 10 μM	Unknown. A large range is used.
CRABP2	Total concentration of CRABP2	1 nM – 10 μM	Unknown. A large range is used.
CYP	Total concentration of CYP	1 nM – 10 μM	Unknown. A large range is used.
RAR	Total concentration of RAR	1 nM – 1 μM	Unknown. A large range is used.
k _d3	Equilibrium dissociation constant of reaction #3	1 nM −64 nM	[6]
k _on13	Forward rate of reaction #13	3.6 × 10⁹ − 3.6 × 10¹⁰	[37]
k _d13	Equilibrium dissociation constant of reaction # 13	0.1 nM–10 nM	[38]
k _on14	Forward rate of reaction #14	50–200 1/h	[5]
k _on15	Forward rate of reaction #15	3.6 × 10⁹ − 3.6 × 10¹⁰	[37]
k _on16	Forward rate of reaction #16	3.6 × 10⁹ − 3.6 × 10¹⁰	[37]
f _RAR	Transcription factor fraction for RAR gene	0–1	By definition
f _CRABP2	Transcription factor fraction of CRABP2 gene	0–1	By definition
f _CYP	Transcription factor fraction for CYP gene	0–1	By definition
f _GOI	Transcription factor fraction for the GOI	0–1	By definition

Reactions are shown in Table 2
Transcription factor fractions are defined in Section “Gene expression through RA pathway”

ISSN: 1742-4682