TY - JOUR AU - Kumar, G. AU - Kumar, N. AU - Taneja, A. AU - Kaleekal, T. AU - Tarima, S. AU - McGinley, E. AU - Jimenez, E. AU - Mohan, A. AU - Khan, R. A. AU - Whittle, J. AU - Jacobs, E. AU - Nanchal, R. PY - 2011 DA - 2011// TI - Nationwide trends of severe sepsis in the 21st century (2000-2007) JO - Chest VL - 140 ID - Kumar2011 ER - TY - STD TI - The World Sepsis Day Fact Sheet. 2013. https://www.uclahealth.org/sepsis/workfiles/Pediatrics/2017_WSD_Declaration_English.pdf. UR - https://www.uclahealth.org/sepsis/workfiles/Pediatrics/2017_WSD_Declaration_English.pdf ID - ref2 ER - TY - STD TI - Singer, M., Deutschman, C. Et.al. The third international consensus definitions for sepsis and septic shock (sepsis-3). J of American Medical Association 2016;315(8), 801–810. ID - ref3 ER - TY - JOUR AU - Cheng, S. C. PY - 2016 DA - 2016// TI - broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis JO - Nat Immunol VL - 17 ID - Cheng2016 ER - TY - JOUR AU - Dellinger, R. P. AU - Schorr, A. S. AU - Levy, M. M. PY - 2017 DA - 2017// TI - A users’ guide to the 2016 surviving Sepsis guidelines JO - Intensive Care Med VL - 43 ID - Dellinger2017 ER - TY - STD TI - Sepsis Management, National Clinical Guideline No.6, https://www.hse.ie/eng/services/publications/clinical-strategy-and-programmes/sepsismanagement.pdf. UR - http://www.hse.ie/eng/about/Who/clinical/natclinprog/sepsis/sepsis%20management.pdf ID - ref6 ER - TY - STD TI - Rami Namas, Ruben Zamora, Rajaie Namas, Gary An, et al. Sepsis: something old, something new, and a systems view. J Crit Care 2012;27(3), 314.e1–314.e11. ID - ref7 ER - TY - JOUR AU - Magni, L. AU - Raimondo, D. M. AU - Bossi, L. AU - Dalla Man, C. AU - Nicolao, G. D. AU - Kovatchev, B. AU - Cobelli, C. PY - 2007 DA - 2007// TI - Model predictive control of type I diabetes: an in silico trial JO - J Diabetes Sci Technol VL - 1 ID - Magni2007 ER - TY - JOUR AU - Kovatchev, B. P. AU - Breton, M. AU - Dalla Man, C. AU - Cobelli, C. PY - 2009 DA - 2009// TI - In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes JO - J Diabetes Sci Technol VL - 3 ID - Kovatchev2009 ER - TY - JOUR AU - Kadota, R. AU - Sugita, K. AU - Uchida, K. AU - Yamada, H. AU - Yamashita, M. AU - Kimura, H. PY - 2018 DA - 2018// TI - A mathematical model of type 1 diabetes involving leptin effects on glucose metabolism JO - J Theor Biol VL - 456 ID - Kadota2018 ER - TY - STD TI - Cloutier M, Wellstead P. Dynamics modeling of protein and oxidative metabolisms simulates the pathogenesis of Parkinson’s disease. IET Syst Biol. 2012:65–72. ID - ref11 ER - TY - STD TI - Wellstead, P. A New Look at Disease,; Parkinson’s as seen through the eyes of an Engineer Control Systems Principle, Stockport UK. 2012. ID - ref12 ER - TY - STD TI - Zuev, S.M., Kingsmore, S.F., Gessler, D.DG. Sepsis Progression and Outcome: a dynamical model. Theoretical Biology and Medical Model. 2006;3 (8). ID - ref13 ER - TY - STD TI - Kendrick, Stuart. F.W., Jones, David E.J. Mechanisms of innate immunity in Sepsis. Chap.2 of Sepsis, Baudouin, S.V.(Ed.) Springer. 2008. ID - ref14 ER - TY - STD TI - Shi Z, Wu C-HJ, Ben-Arieh D, Simpson SQ. Mathematical model of innate and adaptive immunity of Sepsis: a modelling and simulation study of infectious disease. BioMed Research Int. 2015;2015. ID - ref15 ER - TY - JOUR AU - Reynolds, A. AU - Rubin, J. AU - Clermont, G. AU - Day, J. AU - Vodovotz, Y. AU - Ermentrout, G. B. PY - 2006 DA - 2006// TI - A reduced mathematical model of the acute inflammatory response: 1. Derivation of model and analysis of anti-inflammation JO - J Theor Biol VL - 242 ID - Reynolds2006 ER - TY - JOUR AU - Ursino, M. AU - Innocenti, M. PY - 1997 DA - 1997// TI - Modeling arterial hypertension during hemodialysis JO - Artif Organs VL - 21 ID - Ursino1997 ER - TY - JOUR AU - Ursino, M. AU - Antonucci, M. AU - Belardinelli, E. PY - 1994 DA - 1994// TI - Role of active changes in venous capacity by the carotid baroreflex; analysis with a mathematical model JO - Heart and Circulatory Physiology VL - 267 ID - Ursino1994 ER - TY - JOUR AU - Chen, X. H. AU - Yin, Y. J. AU - Zhang, J. X. PY - 2011 DA - 2011// TI - Sepsis and immune response JO - World J Emerg Med VL - 2 ID - Chen2011 ER - TY - JOUR AU - Appenzellar, O. PY - 1987 DA - 1987// TI - The automatic nervous system and fatigue JO - Funct Neurol VL - 2 ID - Appenzellar1987 ER - TY - JOUR AU - Yoshida, J. AU - Yoshino, K. AU - Okada, M. AU - Nakahara, H. AU - Sano, M. AU - Matsunaga, T. PY - 1982 DA - 1982// TI - Sympathetic nervous function during the vertiginous attack in a patient of meniere’s disease JO - Practica Otologica VL - 75 ID - Yoshida1982 ER - TY - JOUR AU - Su, B. AU - Xhou, W. AU - Dorman, K. S. AU - Jones, D. E. PY - 2009 DA - 2009// TI - Mathematical modeling of immune responses in tissues JO - Computational and Mathematical Methods in Medicine VL - 10 ID - Su2009 ER - TY - JOUR AU - Kumar, R. AU - Clermont, G. AU - Vodovotz, Y. AU - Chow, C. C. PY - 2004 DA - 2004// TI - The dynamics of acute inflammation JO - J Theor Biol VL - 230 ID - Kumar2004 ER - TY - JOUR AU - Kitamura, Y. PY - 2018 DA - 2018// TI - Considerations regarding PK/PD theory for antibiotics treatment from a pharmacokinetic perspective JO - Drug Delivery System VL - 33 ID - Kitamura2018 ER - TY - BOOK AU - Hunter, J. PY - 2015 DA - 2015// TI - Cardiovascular systems: clinical concepts and physiology, Foster academics ID - Hunter2015 ER - TY - JOUR AU - Maas, J. J. AU - Pinsky, M. R. AU - Wilde, R. B. AU - Jonge, E. AU - Jansen, J. R. PY - 2013 DA - 2013// TI - Cardiac output response to norepinephrine in postoperative cardiac surgery patients: interpretation with venous return and cardiac function curves JO - Crit Care Med VL - 41 ID - Maas2013 ER - TY - JOUR AU - Annane, D. AU - Bellissant, E. AU - Sebille, V. AU - Lesieur, O. AU - Mathieu, B. AU - Raphael, J. C. AU - Gajdos, P. PY - 1998 DA - 1998// TI - Impaired pressure sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve JO - Br J Clin Pharmacol VL - 46 ID - Annane1998 ER - TY - JOUR AU - Sato, Y. AU - Matsuzawa, H. AU - Eguchi, S. PY - 1982 DA - 1982// TI - Comparative study of effects of adrenaline, Dobutamine and dopamine on systemic hemodynamics and renal blood flow in patients following open heart surgery JO - Jpn Circ J VL - 46 ID - Sato1982 ER - TY - BOOK AU - Ohshima, Y. PY - 1985 DA - 1985// TI - Biochemical dictionary PB - Iwanami CY - Tokyo, Japan ID - Ohshima1985 ER - TY - JOUR AU - Bethell, D. B. PY - 2001 DA - 2001// TI - Noninvasive measurement of microvascular leakage in patients with dengue hemorrhagic fever JO - Clin Infect Dis VL - 32 ID - Bethell2001 ER - TY - JOUR AU - Gamble, J. AU - Christ, F. AU - Gartside, I. B. PY - 1997 DA - 1997// TI - The effect of passive tilting on microvascular parameters in the human calf:a strain gauge plethysmography study JO - J Physiol VL - 498 ID - Gamble1997 ER - TY - JOUR AU - Gamble, J. AU - Gartside, I. B. AU - Christ, F. PY - 1993 DA - 1993// TI - A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man JO - J Physiol VL - 464 ID - Gamble1993 ER - TY - JOUR AU - Suzuki, T. AU - Serita, R. AU - Morisaki, H. PY - 2011 DA - 2011// TI - Myocardial dysfunction in sepsis:cardioprotective strategy and β-blockers JO - Journal of the Japanese Society of Intensive Care Medicine VL - 18 ID - Suzuki2011 ER - TY - STD TI - Ponikowski P. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, ehw. 2015;128. ID - ref34 ER - TY - JOUR AU - Weissler, A. M. AU - Peeler, R. G. AU - Roehll, W. H. PY - 1961 DA - 1961// TI - Relationships between left ventricular ejection time, stroke volume, and heart rate in normal individuals and patients with cardiovascular disease JO - Am Heart J VL - 62 ID - Weissler1961 ER - TY - CHAP AU - Grahame-Smith, D. PY - 2011 DA - 2011// TI - Aronson, J. Oxford textbook of clinical pharmacology and drug therapy, Oxford Univ BT - Press ID - Grahame-Smith2011 ER -