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Fig. 4 | Theoretical Biology and Medical Modelling

Fig. 4

From: MiStImm: an agent-based simulation tool to study the self-nonself discrimination of the adaptive immune response

Fig. 4

Simulation spaces (peptide and antigen lattices) in the ERS model. a A snapshot of the peptide lattice, where the actual TCRs are displayed. With random ‘rings’ around the reflected images of non-immune self antigens (“s”) about one month after birth. A movie capturing a typical simulation of the peptide space is available at the address https://goo.gl/QcdG48. b A snapshot of the antigen lattice, where the actually existing BCRs are displayed. B cell response to a pathogen: large density of pathogen specific B cells at the reflected image of nonself (“n”) about one week after the infection. As a result of negative selection, there are empty domains around the reflected images of non-immune self antigens (‘s’). A movie capturing a typical simulation of the antigen lattice (shape space) is also available at the address https://goo.gl/3oK1bM

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