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Fig. 4 | Theoretical Biology and Medical Modelling

Fig. 4

From: Steady state analysis of influx and transbilayer distribution of ergosterol in the yeast plasma membrane

Fig. 4

Preferred complex formation of sterol in the inner leaflet counteracts increasing sterol release rates in attaining sterol asymmetry in the PM. Steady state transbilayer sterol distribution (ratio Q∙M, Eq. 32) as function of equilibrium constant for sterol complex formation in the outer leaflet (a varying q4) or in the inner leaflet of the PM (b varying q5). The vertical dotted grey line indicates the equilibrium constant for the complex formation in the corresponding other leaflet (i.e., q5 = 1 in a; q4 = 1 in b). While k3 was varied as shown in panel (a), flip-flop rate constants were set to k2 = k− 2 = 1 s− 1, respectively. A ratio Q∙M = 1 corresponds to a symmetric sterol distribution between both leaflets, while Q∙M > 1; Q∙M < 1 means sterol enrichment in the inner and outer leaflet, respectively

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