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Fig. 5 | Theoretical Biology and Medical Modelling

Fig. 5

From: Steady state analysis of influx and transbilayer distribution of ergosterol in the yeast plasma membrane

Fig. 5

Complex formation of sterol in either PM leaflet compared to the ER sets the steady state sterol ratio between both compartments. Steady state sterol distribution between PM and ER (Eq. 46) as a function of equilibrium constant for sterol complex formation in the outer leaflet (a varying q4) or in the inner leaflet of the PM (b varying q5) for differing values of the equilibrium constant for sterol complex formation in the ER. We set q2 = q3 = 1, meaning that forward and backward rate constants for sterol flip flop and for exchange between PM and ER, respectively, are identical. Parameters were k3 = 0.1 s− 1, k2 = 1 s− 1and K7 = 0.01 s− 1, respectively. The equilibrium constant for the complex formation in the corresponding other leaflet was kept constant to q5 = 0.5 in (a) and q4 = 0.5 in (b). See text for further explanations

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