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Fig. 1 | Theoretical Biology and Medical Modelling

Fig. 1

From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism

Fig. 1

Model of nitrogen metabolism and excretion. NH3 in the figure includes both ammonia and ammonium ions. Circles represent reactions (see Table 1 for reaction equations) and ovals represent reactants and products. a Conceptual framework of the in vivo physiology simulated including the many tissues and subcellular compartments involved. b The system is modeled in silico considering only the concentrations of metabolites in the blood. Abbreviations are as follows: GLUL, glutamine synthetase; Gln, glutamine; GLS, glutaminase; CPS1, carbamoyl phosphate synthetase 1; Urea ex, urea excreted; NH3 abs, ammonia absorbed; NH3 ex, ammonia excreted

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