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Table 1 Values for reaction velocities scaled to average male liver mass with recommended protein diet

From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism

Reaction Velocities Parameters from the Literature Organism and Tissue Parameters Scaled to Liver
VNH3 abs = 0.492 mmol/mina
VGLS = (Vmax GLS[Gln])/(Km Gln + [Gln]) Vmax GLS = 91.4 nmole/min per mg [25] Rat Liver Vmax GLS = 28.54 mmol/min
Km Gln = 4.0 mM [26] Human Recombinant Km Gln = 4.0 mM
VNH3 ex = 0.004 mmol/mina
VCPS1 = (Vmax CPS1[NH3])/(Km NH3 + [NH3]) Vmax CPS1 = 45 nmole/min per mg [27] Human Liver Vmax CPS1 = 8.05 mmol/minab
Km NH3 = 0.35 mM [28] Human Recombinant Km NH3 = 0.35 mM
VGLUL = (Vmax GLUL[NH3])/(Km NH3{1  + ([Gln]/Ki Gln)} + [NH3]) Vmax GLUL = 0.47 μmole/15 min per mg [29] Rat Liver Vmax GLUL = 12.3 mmol/minb
Km NH3 = 0.15 mM [30] Human Recombinant Km NH3 = 0.15 mM
Ki Gln = 0.6 mM [31] Bacillis subtilis Ki Gln = 0.6 mM
VUrea ex = 0.244 mmol/mina
  1. aThese values change with protein diet. See methods and discussion for details
  2. bThese values change with liver condition. See methods and discussion for details