Table 3 Parameter changes with altered protein intake and liver condition
From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism
Parameter Name | Protein in Diet (g per day) | Normal Enzyme Activity (mmoles/min) | Enzyme Activity in Liver Cirrhosis (mmoles/min) |
|---|---|---|---|
Urea ex | 71 | 0.244 | 0.244 |
100 | 0.343 | 0.343 | |
122 | 0.417 | 0.417 | |
NH3 ex | 71 | 0.004 | 0.004 |
100 | 0.008 | 0.008 | |
122 | 0.012 | 0.012 | |
NH3 abs | 71 | 0.492 | 0.492 |
100 | 0.693 | 0.693 | |
122 | 0.845 | 0.845 | |
Vmax CPS1 | 71 | 8.05 | 5.64 |
100 | 8.47 | 5.93 | |
122 | 8.78 | 6.146 | |
Vmax GLUL | No change with diet | 12.3 | 2.46 |