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Table 4 Sensitivity analysis for kinetic parameters

From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism

Enzyme Parameter Parameter Percent Change Blood Ammonia Percent Change
CPS1 Vmax 150% −35.4
50% 110.3
Km 150% 52.6
50% −50.3
Glutaminase Vmax 150% 0.6
50% −2.9
Km 150% −1.1
50% 1.1
Glutamine Synthetase Vmax 150% 4.6
50% −4.6
Km 150% −2.9
50% 7.4
Ki 150% 0.6
50% −0.6