Table 4 Sensitivity analysis for kinetic parameters
From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism
Enzyme | Parameter | Parameter Percent Change | Blood Ammonia Percent Change |
|---|---|---|---|
CPS1 | Vmax | 150% | −35.4 |
50% | 110.3 | ||
Km | 150% | 52.6 | |
50% | −50.3 | ||
Glutaminase | Vmax | 150% | 0.6 |
50% | −2.9 | ||
Km | 150% | −1.1 | |
50% | 1.1 | ||
Glutamine Synthetase | Vmax | 150% | 4.6 |
50% | −4.6 | ||
Km | 150% | −2.9 | |
50% | 7.4 | ||
Ki | 150% | 0.6 | |
50% | −0.6 |