TY - JOUR AU - Abdirizak, Fatima AU - Lewis, Rayleen AU - Chowell, Gerardo PY - 2019 DA - 2019/10/07 TI - Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting JO - Theoretical Biology and Medical Modelling SP - 16 VL - 16 IS - 1 AB - Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continues to pose a significant threat in the Middle East since 2012. Currently, no licensed vaccine or drug treatment is available to treat patients infected with either coronavirus. However, there are some MERS vaccines in the preclinical stage of development. We sought to evaluate the potential impact of targeted vaccination strategies for mitigating SARS and MERS outbreaks in healthcare settings using simple mathematical models and detailed historic transmission trees describing the progression of past nosocomial outbreaks of SARS and MERS. SN - 1742-4682 UR - https://doi.org/10.1186/s12976-019-0112-6 DO - 10.1186/s12976-019-0112-6 ID - Abdirizak2019 ER -