Table 1 Parameters and their descriptions (protein concentrations are in arbitrary units, and the unit of time is h)
Parameter | Significance | Value |
|---|---|---|
k 1 | rate of Bcl2 synthesis | 0.05 |
k 2 | basal rate of Bcl2 degradation | 0.01 |
k 3 | stress-dependent rate of Bcl2 degradation | 0.6 |
k 4 | Caspases-dependent rate of Bcl2 degradation | 0.1 |
k 5 | AMBRA1-dependent rate of ER-Bcl2 degradation | 0.3 |
k 6 | AMBRA1-dependent rate of mito-Bcl2 degradation | 0.4 |
k 7 | basal rate of AMBRA1 activation | 0.001 |
k 8 | ER-Bcl2-dependent rate of AMBRA1 degradation | 0.3 |
k 9 | mito-Bcl2-dependent rate of AMBRA1 degradation | 0.4 |
k 10 | basal rate of AMBRA1 inactivation | 0.01 |
k 11 | AMBRA1-dependent rate of Beclin1 activation | 0.3 |
k 12 | basal rate of Caspases activation | 0 |
k 13 | inactivated Beclin1-dependent Caspases activation constant | 0.05 |
k 14 | Bax-dependent rate of Caspases activation | 0.4 |
k 15 | basal Caspases inactivation constant | 0.1 |
k 16 | Beclin1-dependent rate of Caspases inactivation | 0.37 |
k 17 | Beclin1activation rate | 1 |
k 18 | basal Beclin1inactivation rate | 0.01 |
k 19 | Caspases-dependent rate of Beclin1 inactivation | 5 |
Jcp | Caspases Michaelis constant | 0.01 |
k a | rate of Bcl2-Beclin1 complex association | 0.1 |
k b | rate of Bcl2-Beclin1 complex dissociation | 1 |
k c | rate of Bcl2-Bax complex association | 8 |
k d | rate of Bcl2-Bax complex dissociation | 0.1 |
S1, S2 | stress level S1 and S2 | 0.5 |
Bcl2t | total level of Bcl2 | 1 |
Baxt | total level of Bax | 0.25 |
Caspt | total level of Caspases | 1 |
Becic | inactive, Bcl2-bounded Beclin1 | 0.2 |
Bect | total level of Beclin1 | 1 |