k
_{1}

rate of Bcl2 synthesis

0.05

k
_{2}

basal rate of Bcl2 degradation

0.01

k
_{3}

stressdependent rate of Bcl2 degradation

0.6

k
_{4}

Caspasesdependent rate of Bcl2 degradation

0.1

k
_{5}

AMBRA1dependent rate of ERBcl2 degradation

0.3

k
_{6}

AMBRA1dependent rate of mitoBcl2 degradation

0.4

k
_{7}

basal rate of AMBRA1 activation

0.001

k
_{8}

ERBcl2dependent rate of AMBRA1 degradation

0.3

k
_{9}

mitoBcl2dependent rate of AMBRA1 degradation

0.4

k
_{10}

basal rate of AMBRA1 inactivation

0.01

k
_{11}

AMBRA1dependent rate of Beclin1 activation

0.3

k
_{12}

basal rate of Caspases activation

0

k
_{13}

inactivated Beclin1dependent Caspases activation constant

0.05

k
_{14}

Baxdependent rate of Caspases activation

0.4

k
_{15}

basal Caspases inactivation constant

0.1

k
_{16}

Beclin1dependent rate of Caspases inactivation

0.37

k
_{17}

Beclin1activation rate

1

k
_{18}

basal Beclin1inactivation rate

0.01

k
_{19}

Caspasesdependent rate of Beclin1 inactivation

5

Jcp

Caspases Michaelis constant

0.01

k
_{
a}

rate of Bcl2Beclin1 complex association

0.1

k
_{
b}

rate of Bcl2Beclin1 complex dissociation

1

k
_{
c}

rate of Bcl2Bax complex association

8

k
_{
d}

rate of Bcl2Bax complex dissociation

0.1

S_{1}, S_{2}

stress level S_{1} and S_{2}

0.5

Bcl2t

total level of Bcl2

1

Baxt

total level of Bax

0.25

Caspt

total level of Caspases

1

Becic

inactive, Bcl2bounded Beclin1

0.2

Bect

total level of Beclin1

1
